Identification of Two Prion Protein Regions That Modify Scrapie Incubation Time

A series of prion transmission experiments was performed in transgenic (Tg) mice expressing either wild-type, chimeric, or truncated prion protein (PrP) molecules. Following inoculation with Rocky Mountain Laboratory (RML) murine prions, scrapie incubation times for Tg(MoPrP)4053, Tg(MHM2)294/Prnp(0...

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Autors principals: Supattapone, Surachai, Muramoto, Tamaki, Legname, Giuseppe, Mehlhorn, Ingrid, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B., Scott, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC114047/
https://ncbi.nlm.nih.gov/pubmed/11152514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.3.1408-1413.2001
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