Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

BACKGROUND: Microvascular injury plays a key role in normal tissue radiation responses. Statins, in addition to their lipid-lowering effects, have vasculoprotective properties that may counteract some effects of radiation on normal tissues. We examined whether administration of simvastatin ameliorat...

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Hlavní autoři: Wang, Junru, Boerma, Marjan, Fu, Qiang, Kulkarni, Ashwini, Fink, Louis M., Hauer-Jensen, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000701/
https://ncbi.nlm.nih.gov/pubmed/17674978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2007.03.036
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