γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism

Analogs of vitamin E (tocols) are under development as radioprophylactic agents because of their high efficacy and lack of toxicity. Gamma-tocotrienol (GT3) is of particular interest because, in addition to being an antioxidant, it also inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct...

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Main Authors: Berbée, Maaike, Fu, Qiang, Boerma, Marjan, Wang, Junru, Kumar, K. Sree, Hauer-Jensen, Martin
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713014/
https://ncbi.nlm.nih.gov/pubmed/19580495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1632.1
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