The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal Mucosa and Increases Survival after Total-Body Irradiation by Inhibiting Exocrine Pancreatic Secretion

Somatostatin analogs ameliorate intestinal injury after localized irradiation. This study investigated whether SOM230, a novel, metabolically stable analog with broad receptor affinity, reduces intestinal injury and lethality in mice exposed to total-body irradiation (TBI). Male CD2F1 mice were expo...

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Autores principales: Fu, Qiang, Berbée, Maaike, Boerma, Marjan, Wang, Junru, Schmid, Herbert A., Hauer-Jensen, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742953/
https://ncbi.nlm.nih.gov/pubmed/19580476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1685.1
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