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Inhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat model
SUMMARY: Direct inhibition of thrombin has a beneficial effect on intestinal radiation toxicity. A small molecule inhibitor of protease-activated receptor 1 (PAR1), the most relevant receptor for thrombin, was administered to rats undergoing localized, fractionated irradiation of a segment of small...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462888/ https://ncbi.nlm.nih.gov/pubmed/22580123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2012.02.007 |
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