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TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

Erk1/Erk2 MAP kinases are key regulators of cell behaviour and their activation is generally associated with tyrosine kinase signalling. However, TGF-β stimulation also activates Erk MAP kinases through an undefined mechanism, albeit to a much lower level than receptor tyrosine kinase stimulation. W...

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Detalhes bibliográficos
Main Authors: Lee, Matt K, Pardoux, Cécile, Hall, Marie C, Lee, Pierre S, Warburton, David, Qing, Jing, Smith, Susan M, Derynck, Rik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994119/
https://ncbi.nlm.nih.gov/pubmed/17673906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601818
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