Processive phosphorylation of ERK MAP kinase in mammalian cells

The mitogen-activated protein (MAP) kinase pathway is comprised of a three-tiered kinase cascade. The distributive kinetic mechanism of two-site MAP kinase phosphorylation inherently generates a nonlinear switch-like response. However, a linear graded response of MAP kinase has also been observed in...

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Bibliografske podrobnosti
Main Authors: Aoki, Kazuhiro, Yamada, Masashi, Kunida, Katsuyuki, Yasuda, Shuhei, Matsuda, Michiyuki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150946/
https://ncbi.nlm.nih.gov/pubmed/21768338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104030108
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