Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120

Spinal cord glia (microglia and astrocytes) contribute to enhanced pain states. One model that has been used to study this phenomenon is intrathecal (i.t.) administration of gp120, an envelope glycoprotein of HIV-1 known to activate spinal cord glia and thereby induce low-threshold mechanical allody...

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Main Authors: Schoeniger-Skinner, Diana K., Ledeboer, Annemarie, Frank, Matthew G., Milligan, Erin D., Poole, Stephen, Martin, David, Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1991283/
https://ncbi.nlm.nih.gov/pubmed/17204394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2006.10.010
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