Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120

Spinal cord glia (microglia and astrocytes) contribute to enhanced pain states. One model that has been used to study this phenomenon is intrathecal (i.t.) administration of gp120, an envelope glycoprotein of HIV-1 known to activate spinal cord glia and thereby induce low-threshold mechanical allody...

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Autori principali: Schoeniger-Skinner, Diana K., Ledeboer, Annemarie, Frank, Matthew G., Milligan, Erin D., Poole, Stephen, Martin, David, Maier, Steven F., Watkins, Linda R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1991283/
https://ncbi.nlm.nih.gov/pubmed/17204394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2006.10.010
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