Intrathecal HIV-1 Envelope Glycoprotein gp120 Induces Enhanced Pain States Mediated by Spinal Cord Proinflammatory Cytokines

Perispinal (intrathecal) injection of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 creates exaggerated pain states. Decreases in response thresholds to both heat stimuli (thermal hyperalgesia) and light tactile stimuli (mechanical allodynia) are rapidly induced after gp120...

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Publicat a:J Neurosci
Autors principals: Milligan, Erin D., O'Connor, Kevin A., Nguyen, Kien T., Armstrong, Charles B., Twining, Carin, Gaykema, Ron P. A., Holguin, Adelina, Martin, David, Maier, Steven F., Watkins, Linda R.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2001
Matèries:
ARTICLE
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762530/
https://ncbi.nlm.nih.gov/pubmed/11306633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-08-02808.2001
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