A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

The molecular basis of the erythrocytosis group of red cell disorders is incompletely defined. Some cases are due to dysregulation of erythropoietin (Epo) synthesis. The hypoxia inducible transcription factor (HIF) tightly regulates Epo synthesis. HIF in turn is regulated through its α subunit, whic...

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Bibliografiske detaljer
Main Authors: Percy, Melanie J., Furlow, Paul W., Beer, Philip A., Lappin, Terence R. J., McMullin, Mary Frances, Lee, Frank S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Red Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976349/
https://ncbi.nlm.nih.gov/pubmed/17579185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084434
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