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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
The molecular basis of the erythrocytosis group of red cell disorders is incompletely defined. Some cases are due to dysregulation of erythropoietin (Epo) synthesis. The hypoxia inducible transcription factor (HIF) tightly regulates Epo synthesis. HIF in turn is regulated through its α subunit, whic...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976349/ https://ncbi.nlm.nih.gov/pubmed/17579185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084434 |
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