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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
The molecular basis of the erythrocytosis group of red cell disorders is incompletely defined. Some cases are due to dysregulation of erythropoietin (Epo) synthesis. The hypoxia inducible transcription factor (HIF) tightly regulates Epo synthesis. HIF in turn is regulated through its α subunit, whic...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976349/ https://ncbi.nlm.nih.gov/pubmed/17579185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084434 |
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