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A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis
Hypoxia-inducible factor (HIF) α, which has three isoforms, is central to the continuous balancing of the supply and demand of oxygen throughout the body. HIF-α is a transcription factor that modulates a wide range of processes, including erythropoiesis, angiogenesis, and cellular metabolism. We des...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2295209/ https://ncbi.nlm.nih.gov/pubmed/18184961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa073123 |
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