Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline

A classic physiologic response to hypoxia in humans is the up-regulation of the ERYTHROPOIETIN (EPO) gene, which is the central regulator of red blood cell mass. The EPO gene, in turn, is activated by hypoxia inducible factor (HIF). HIF is a transcription factor consisting of an α subunit (HIF-α) an...

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Main Authors: Furlow, Paul W., Percy, Melanie J., Sutherland, Scott, Bierl, Charlene, McMullin, Mary Frances, Master, Stephen R., Lappin, Terence R. J., Lee, Frank S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666553/
https://ncbi.nlm.nih.gov/pubmed/19208626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808737200
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