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Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by immune assault or the lack of compensation to overcome insulin resistance. Elucidating the mechanisms that regulate β cell mass has important ramifications for fostering β cell regeneration and the tr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1964513/ https://ncbi.nlm.nih.gov/pubmed/17823659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32198 |
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