Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells

Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by immune assault or the lack of compensation to overcome insulin resistance. Elucidating the mechanisms that regulate β cell mass has important ramifications for fostering β cell regeneration and the tr...

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Main Authors: Zhong, Lingwen, Georgia, Senta, Tschen, Shuen-ing, Nakayama, Keiko, Nakayama, Keiichi, Bhushan, Anil
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2007
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964513/
https://ncbi.nlm.nih.gov/pubmed/17823659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32198
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