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Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx
Adult pancreatic beta cells can replicate during growth and after injury to maintain glucose homeostasis. Here we report that beta cells deficient in Dnmt1, an enzyme that propagates DNA methylation patterns during cell division, were converted to alpha cells. We identified the lineage determination...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086024/ https://ncbi.nlm.nih.gov/pubmed/21497756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.03.012 |
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