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DNA methylation directs functional maturation of pancreatic β cells

Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect against hypoglycemia. β cells lack this functional capability at birth and acquire glucose-stimulated insulin secretio...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Dhawan, Sangeeta, Tschen, Shuen-Ing, Zeng, Chun, Guo, Tingxia, Hebrok, Matthias, Matveyenko, Aleksey, Bhushan, Anil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563682/
https://ncbi.nlm.nih.gov/pubmed/26098213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79956
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