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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation
The molecular mechanisms that regulate the age-induced increase of p16(INK4a) expression associated with decreased β-cell proliferation and regeneration are not well understood. We report that in aged islets, derepression of the Ink4a/Arf locus is associated with decreased Bmi-1 binding, loss of H2A...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675870/ https://ncbi.nlm.nih.gov/pubmed/19390085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1742609 |
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