Skp2 Is Required for Incretin Hormone-Mediated β-Cell Proliferation

The glucoincretin hormone glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (Ex-4) promote β-cell growth and expansion. Here we report an essential role for Skp2, a substrate recognition component of SCF (Skp, Cullin, F-box) ubiquitin ligase, in promoting glucoincretin-induced β-cell prolifer...

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Detalhes bibliográficos
Main Authors: Tschen, Shuen-Ing, Georgia, Senta, Dhawan, Sangeeta, Bhushan, Anil
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231831/
https://ncbi.nlm.nih.gov/pubmed/21980072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1119
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