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Skp2 Is Required for Incretin Hormone-Mediated β-Cell Proliferation
The glucoincretin hormone glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (Ex-4) promote β-cell growth and expansion. Here we report an essential role for Skp2, a substrate recognition component of SCF (Skp, Cullin, F-box) ubiquitin ligase, in promoting glucoincretin-induced β-cell prolifer...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Endocrine Society
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3231831/ https://ncbi.nlm.nih.gov/pubmed/21980072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1119 |
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