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Latent ClpX-recognition signals ensure LexA destruction after DNA damage

The DNA-damage response genes in bacteria are up-regulated when LexA repressor undergoes autocatalytic cleavage stimulated by activated RecA protein. Intact LexA is stable to intracellular degradation but its auto-cleavage fragments are degraded rapidly. Here, both fragments of LexA are shown to be...

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Detalhes bibliográficos
Main Authors: Neher, Saskia B., Flynn, Julia M., Sauer, Robert T., Baker, Tania A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196044/
https://ncbi.nlm.nih.gov/pubmed/12730132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1078003
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