Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

Aberrant activation of Wnt signaling is oncogenic and has been implicated in a variety of human cancers. We have developed a doxycycline-inducible Wnt1 transgenic mouse model to determine the dependence of established mammary adenocarcinomas on continued Wnt signaling. Using this model we show that...

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Autors principals: Gunther, Edward J., Moody, Susan E., Belka, George K., Hahn, Kristina T., Innocent, Nathalie, Dugan, Katherine D., Cardiff, Robert D., Chodosh, Lewis A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2003
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC195997/
https://ncbi.nlm.nih.gov/pubmed/12600942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1051603
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