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Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
Aberrant activation of Wnt signaling is oncogenic and has been implicated in a variety of human cancers. We have developed a doxycycline-inducible Wnt1 transgenic mouse model to determine the dependence of established mammary adenocarcinomas on continued Wnt signaling. Using this model we show that...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC195997/ https://ncbi.nlm.nih.gov/pubmed/12600942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1051603 |
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