Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19(Arf)/p53 pathway lesions but not p16(Ink4a) loss

Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated genetic determinants underlying tumor escape in a transgenic mouse model of Wnt pathway–driven breast cancer, wherein targeted therapy is sim...

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Bibliografiske detaljer
Main Authors: Debies, Michael T., Gestl, Shelley A., Mathers, Jessica L., Mikse, Oliver R., Leonard, Travis L., Moody, Susan E., Chodosh, Lewis A., Cardiff, Robert D., Gunther, Edward J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104482/
https://ncbi.nlm.nih.gov/pubmed/18060046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33320
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