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The S631A Mutation Causes a Mechanistic Switch in the Block of hERG Channels by CnErg1
We have studied the interaction of CnErg1, a member of the γ-KTX subfamily of scorpion toxins with the inactivation-deficient S631A hERG channel. In the background of this mutation, we observed a mechanistic switch from turret block, characteristic of the action of γ-KTXs on Kv11-type channels, to p...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Biophysical Society
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1959546/ https://ncbi.nlm.nih.gov/pubmed/17631536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.114561 |
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