Φορτώνει......
Control of the B Cell-Intrinsic Tolerance Program by c-Cbl and Cbl-b
BCR signaling plays a critical role in B-cell tolerance and activation. Here, we show that mice with B cell-specific ablation of both c-Cbl and Cbl-b (Cbl-dko) manifest systemic lupus erythymatosis (SLE)-like autoimmune disease. The Cbl-dko mutation results in a significant increase in marginal zone...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948079/ https://ncbi.nlm.nih.gov/pubmed/17493844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.03.015 |
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