Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells

Genetic studies have revealed that Cbl-b plays a negative role in the antigen receptor–mediated proliferation of lymphocytes. However, we show that Cbl-b–deficient DT40 B cells display reduced phospholipase C (PLC)-γ2 activation and Ca(2+) mobilization upon B cell receptor (BCR) stimulation. In addi...

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Autores principales: Yasuda, Tomoharu, Tezuka, Tohru, Maeda, Akito, Inazu, Tetsuya, Yamanashi, Yuji, Gu, Hua, Kurosaki, Tomohiro, Yamamoto, Tadashi
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194016/
https://ncbi.nlm.nih.gov/pubmed/12093870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020068
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