Control of the B Cell-Intrinsic Tolerance Program by c-Cbl and Cbl-b

BCR signaling plays a critical role in B-cell tolerance and activation. Here, we show that mice with B cell-specific ablation of both c-Cbl and Cbl-b (Cbl-dko) manifest systemic lupus erythymatosis (SLE)-like autoimmune disease. The Cbl-dko mutation results in a significant increase in marginal zone...

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Main Authors: Kitaura, Yasuyuki, Jang, Ihn-Kyung, Wang, Yan, Han, Yoon-Chi, Inazu, Tetsuya, Cadera, Emily J., Schlissel, Mark, Hardy, Richard R., Gu, Hua
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948079/
https://ncbi.nlm.nih.gov/pubmed/17493844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.03.015
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