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Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation
Casitas B-lineage lymphoma-b (Cbl-b) is an E3 ubiquitin ligase that negatively regulates T cell activation. Cbl-b(−/−) T cells are hyper-reactive and co-stimulation independent, and Cbl-b(−/−) mice demonstrate robust T cell and NK cell-mediated antitumor immunity. As a result of these murine studies...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5266705/ https://ncbi.nlm.nih.gov/pubmed/28184224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00042 |
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