Acquisition of Anoikis Resistance Promotes the Emergence of Oncogenic K-ras Mutations in Colorectal Cancer Cells and Stimulates Their Tumorigenicity In Vivo

Detachment from the extracellular matrix causes apoptosis of normal epithelial cells—a phenomenon called anoikis. K-ras oncogene, an established anoikis inhibitor, often occurs in colorectal carcinoma (CRC). In addition to blocking anoikis-inducing mechanisms, oncogenic K-ras can cause anoikis-unrel...

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Main Authors: Derouet, Mathieu, Wu, Xue, May, Linda, Hoon Yoo, Byong, Sasazuki, Takehiko, Shirasawa, Senji, Rak, Janusz, Rosen, Kirill V
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2007
主題:
Brief Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939928/
https://ncbi.nlm.nih.gov/pubmed/17710156
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