Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that R...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Yoo, Byong Hoon, Khan, Iman Aftab, Koomson, Ananda, Gowda, Pramod, Sasazuki, Takehiko, Shirasawa, Senji, Gujar, Shashi, V. Rosen, Kirill
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846558/
https://ncbi.nlm.nih.gov/pubmed/28933585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1370171
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