Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that R...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Yoo, Byong Hoon, Khan, Iman Aftab, Koomson, Ananda, Gowda, Pramod, Sasazuki, Takehiko, Shirasawa, Senji, Gujar, Shashi, V. Rosen, Kirill
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846558/
https://ncbi.nlm.nih.gov/pubmed/28933585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1370171
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