Oncogenic ras-induced Down-regulation of Pro-apoptotic Protease Caspase-2 Is Required for Malignant Transformation of Intestinal Epithelial Cells

Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade adjacent tissues, and metastasize to distant organs. Current knowledge about the mec...

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Main Authors: Yoo, Byong Hoon, Wang, Yanfei, Erdogan, Mete, Sasazuki, Takehiko, Shirasawa, Senji, Corcos, Laurent, Sabapathy, Kanaga, Rosen, Kirill V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234714/
https://ncbi.nlm.nih.gov/pubmed/21903589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290692
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