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Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells

Detachment of nonmalignant intestinal epithelial cells from the extracellular matrix (ECM) triggers their growth arrest and, ultimately, apoptosis. In contrast, colorectal cancer cells can grow without attachment to the ECM. This ability is critical for their malignant potential. We found previously...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Yoo, Byong Hoon, Zagryazhskaya, Anna, Li, Yongling, Koomson, Ananda, Khan, Iman Aftab, Sasazuki, Takehiko, Shirasawa, Senji, Rosen, Kirill V
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590629/
https://ncbi.nlm.nih.gov/pubmed/26061804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1056968
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