Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells

Detachment of nonmalignant intestinal epithelial cells from the extracellular matrix (ECM) triggers their growth arrest and, ultimately, apoptosis. In contrast, colorectal cancer cells can grow without attachment to the ECM. This ability is critical for their malignant potential. We found previously...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Yoo, Byong Hoon, Zagryazhskaya, Anna, Li, Yongling, Koomson, Ananda, Khan, Iman Aftab, Sasazuki, Takehiko, Shirasawa, Senji, Rosen, Kirill V
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590629/
https://ncbi.nlm.nih.gov/pubmed/26061804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1056968
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