Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that R...

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Vydáno v:Autophagy
Hlavní autoři: Yoo, Byong Hoon, Khan, Iman Aftab, Koomson, Ananda, Gowda, Pramod, Sasazuki, Takehiko, Shirasawa, Senji, Gujar, Shashi, V. Rosen, Kirill
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846558/
https://ncbi.nlm.nih.gov/pubmed/28933585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1370171
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