Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that R...

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Publicado en:Autophagy
Autores principales: Yoo, Byong Hoon, Khan, Iman Aftab, Koomson, Ananda, Gowda, Pramod, Sasazuki, Takehiko, Shirasawa, Senji, Gujar, Shashi, V. Rosen, Kirill
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846558/
https://ncbi.nlm.nih.gov/pubmed/28933585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1370171
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