Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

Targeted disruption of the single mutant K-ras allele in two human colorectal carcinoma cell lines (DLD-1 and HCT-116) leads to loss of tumorigenic competence in nude mice with retention of ability to grow indefinitely in monolayer culture. Because expression of the mutant K-ras oncogene in these ce...

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Main Authors: Okada, Futoshi, Rak, Janusz W., Croix, Brad St., Lieubeau, Blandine, Kaya, Mitsunori, Roncari, Luba, Shirasawa, Senji, Sasazuki, Takehiko, Kerbel, Robert S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19883/
https://ncbi.nlm.nih.gov/pubmed/9520413
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