CpG Methylation of DNA Restricts Prereplication Complex Assembly in Xenopus Egg Extracts

In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG methylated DNA and DNA replication is inhibited. Insertion of low density CpG DNA of at least 1.2 kb into methylated plasmids rescues both replication and ORC binding. Using this pseudo-origin, we find tha...

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書目詳細資料

發表在:	Mol Cell Biol
Principais autores:	Harvey, Kevin J., Newport, John
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 2003
主題:	DNA Dynamics and Chromosome Structure
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12972597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.19.6769-6779.2003
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