CpG Methylation of DNA Restricts Prereplication Complex Assembly in Xenopus Egg Extracts

In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG methylated DNA and DNA replication is inhibited. Insertion of low density CpG DNA of at least 1.2 kb into methylated plasmids rescues both replication and ORC binding. Using this pseudo-origin, we find tha...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Harvey, Kevin J., Newport, John
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12972597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.19.6769-6779.2003
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