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CpG Methylation of DNA Restricts Prereplication Complex Assembly in Xenopus Egg Extracts
In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG methylated DNA and DNA replication is inhibited. Insertion of low density CpG DNA of at least 1.2 kb into methylated plasmids rescues both replication and ORC binding. Using this pseudo-origin, we find tha...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology
2003
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC193934/ https://ncbi.nlm.nih.gov/pubmed/12972597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.6769-6779.2003 |
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