CpG Methylation of DNA Restricts Prereplication Complex Assembly in Xenopus Egg Extracts

In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG methylated DNA and DNA replication is inhibited. Insertion of low density CpG DNA of at least 1.2 kb into methylated plasmids rescues both replication and ORC binding. Using this pseudo-origin, we find tha...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Harvey, Kevin J., Newport, John
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	DNA Dynamics and Chromosome Structure
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12972597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.19.6769-6779.2003
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