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CpG Methylation of DNA Restricts Prereplication Complex Assembly in Xenopus Egg Extracts

In a Xenopus egg replication system, the origin recognition complex (ORC) does not bind to CpG methylated DNA and DNA replication is inhibited. Insertion of low density CpG DNA of at least 1.2 kb into methylated plasmids rescues both replication and ORC binding. Using this pseudo-origin, we find tha...

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Hlavní autoři: Harvey, Kevin J., Newport, John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC193934/
https://ncbi.nlm.nih.gov/pubmed/12972597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.6769-6779.2003
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