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RPA and ATR link transcriptional stress to p53

The mechanisms by which DNA-damaging agents trigger the induction of the stress response protein p53 are poorly understood but may involve alterations of chromatin structure or blockage of either transcription or replication. Here we show that transcription-blocking agents can induce phosphorylation...

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Detalhes bibliográficos
Main Authors: Derheimer, Frederick A., O'Hagan, Heather M., Krueger, Heather M., Hanasoge, Sheela, Paulsen, Michelle T., Ljungman, Mats
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937543/
https://ncbi.nlm.nih.gov/pubmed/17616578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705317104
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