Activation of CB(2) cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

We designed AM1241, a selective CB(2) cannabinoid receptor agonist, and used it to test the hypothesis that CB(2) receptor activation would reverse the sensory hypersensitivity observed in neuropathic pain states. AM1241 exhibits high affinity and selectivity for CB(2) receptors. It also exhibits hi...

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Bibliographische Detailangaben
Hauptverfasser: Ibrahim, Mohab M., Deng, Hongfeng, Zvonok, Alexander, Cockayne, Debra A., Kwan, Joyce, Mata, Heriberto P., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Makriyannis, Alexandros, Malan, T. Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC193595/
https://ncbi.nlm.nih.gov/pubmed/12917492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834309100
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