Activation of CB(2) cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

We designed AM1241, a selective CB(2) cannabinoid receptor agonist, and used it to test the hypothesis that CB(2) receptor activation would reverse the sensory hypersensitivity observed in neuropathic pain states. AM1241 exhibits high affinity and selectivity for CB(2) receptors. It also exhibits hi...

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Autori principali: Ibrahim, Mohab M., Deng, Hongfeng, Zvonok, Alexander, Cockayne, Debra A., Kwan, Joyce, Mata, Heriberto P., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Makriyannis, Alexandros, Malan, T. Philip
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC193595/
https://ncbi.nlm.nih.gov/pubmed/12917492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834309100
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