Activation of CB(2) cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

We designed AM1241, a selective CB(2) cannabinoid receptor agonist, and used it to test the hypothesis that CB(2) receptor activation would reverse the sensory hypersensitivity observed in neuropathic pain states. AM1241 exhibits high affinity and selectivity for CB(2) receptors. It also exhibits hi...

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Detalhes bibliográficos
Main Authors: Ibrahim, Mohab M., Deng, Hongfeng, Zvonok, Alexander, Cockayne, Debra A., Kwan, Joyce, Mata, Heriberto P., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Makriyannis, Alexandros, Malan, T. Philip
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193595/
https://ncbi.nlm.nih.gov/pubmed/12917492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834309100
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