Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

The low-density lipoprotein (LDL) receptor (LDLR) binds to and internalizes lipoproteins that contain apolipoproteinB100 (apoB100) or apolipoproteinE (apoE). Internalization of the apoB100 lipoprotein ligand, LDL, requires the FDNPVY(807) sequence on the LDLR cytoplasmic domain, which binds to the e...

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Autori principali: Michaely, Peter, Zhao, Zhenze, Li, Wei-Ping, Garuti, Rita, Huang, Lily J, Hobbs, Helen H, Cohen, Jonathan C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933400/
https://ncbi.nlm.nih.gov/pubmed/17581630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601769
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