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An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9 and LDLR in Hepatocytes

ApoB Lipoproteins (apoB-Lp) are produced in hepatocytes and their secretion requires the cargo receptor sortilin. We examined the secretion of apoB-Lp-containing very low-density lipoprotein (VLDL), an LDL progenitor. Sortilin also regulates the trafficking of the subtilase PCSK9, which when secrete...

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Publicat a:Biochemistry
Autors principals: Sparks, Robert P., Arango, Andres S., Jenkins, Jermaine L., Guida, Wayne C., Tajkhorshid, Emad, Sparks, Charles E., Sparks, Janet D., Fratti, Rutilio A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674269/
https://ncbi.nlm.nih.gov/pubmed/33153264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00741
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