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An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9 and LDLR in Hepatocytes
ApoB Lipoproteins (apoB-Lp) are produced in hepatocytes and their secretion requires the cargo receptor sortilin. We examined the secretion of apoB-Lp-containing very low-density lipoprotein (VLDL), an LDL progenitor. Sortilin also regulates the trafficking of the subtilase PCSK9, which when secrete...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7674269/ https://ncbi.nlm.nih.gov/pubmed/33153264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00741 |
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