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Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. Inactivating mut...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular
Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413232/ https://ncbi.nlm.nih.gov/pubmed/22764087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M028563 |
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