Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. Inactivating mut...

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Autors principals: Wang, Yan, Huang, Yongcheng, Hobbs, Helen H., Cohen, Jonathan C.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413232/
https://ncbi.nlm.nih.gov/pubmed/22764087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M028563
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