Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo

Human immunodeficiency virus type 1 (HIV-1) infection causes apoptosis of infected CD4 T cells as well as uninfected (bystander) CD4 and CD8 T cells. It remains unknown what signals cause infected cells to die. We demonstrate that HIV-1 protease specifically cleaves procaspase 8 to create a novel fr...

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Hlavní autoři: Nie, Zilin, Bren, Gary D., Vlahakis, Stacey R., Schimnich, Alicia Algeciras, Brenchley, Jason M., Trushin, Sergey A., Warren, Sarah, Schnepple, David J., Kovacs, Colin M., Loutfy, Mona R., Douek, Daniel C., Badley, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933285/
https://ncbi.nlm.nih.gov/pubmed/17442709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02798-06
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