Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo

Human immunodeficiency virus type 1 (HIV-1) infection causes apoptosis of infected CD4 T cells as well as uninfected (bystander) CD4 and CD8 T cells. It remains unknown what signals cause infected cells to die. We demonstrate that HIV-1 protease specifically cleaves procaspase 8 to create a novel fr...

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Main Authors: Nie, Zilin, Bren, Gary D., Vlahakis, Stacey R., Schimnich, Alicia Algeciras, Brenchley, Jason M., Trushin, Sergey A., Warren, Sarah, Schnepple, David J., Kovacs, Colin M., Loutfy, Mona R., Douek, Daniel C., Badley, Andrew D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933285/
https://ncbi.nlm.nih.gov/pubmed/17442709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02798-06
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