Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo

Human immunodeficiency virus type 1 (HIV-1) infection causes apoptosis of infected CD4 T cells as well as uninfected (bystander) CD4 and CD8 T cells. It remains unknown what signals cause infected cells to die. We demonstrate that HIV-1 protease specifically cleaves procaspase 8 to create a novel fr...

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Detalhes bibliográficos
Main Authors: Nie, Zilin, Bren, Gary D., Vlahakis, Stacey R., Schimnich, Alicia Algeciras, Brenchley, Jason M., Trushin, Sergey A., Warren, Sarah, Schnepple, David J., Kovacs, Colin M., Loutfy, Mona R., Douek, Daniel C., Badley, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933285/
https://ncbi.nlm.nih.gov/pubmed/17442709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02798-06
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